Because fibromyalgia involves frequent bouts of pain that can occur throughout the body, there’s a common misperception that people with the condition should avoid exercise since it may worsen that pain. While overdoing it can exacerbate symptoms, finding the types of exercise you can tolerate — and remaining within your limits once you do —…

The Guaifenesin Protocol for Fibromyalgia By Adrienne Dellwo Updated Medically reviewed by David Ozeri, MD Key Takeaways The Guaifenesin Protocol for fibromyalgia is not supported by scientific evidence and may not be effective. People following the protocol must avoid all sources of salicylates, which can be difficult. The Guaifenesin Protocol is an unproven treatment for…

Fibromyalgia is something of a mystery. It can’t be detected with scans or blood tests, yet it causes lifelong pain for millions of people. The disease mainly affects women (about 75-90% of cases), causing pain all over the body. Because not all healthcare professionals are adept at identifying and diagnosing fibromyalgia, reported rates of the…

Women with Cushing’s syndrome may be misdiagnosed with fibromyalgia — a chronic condition characterized by widespread pain and mental distress — despite showing Cushing’s symptoms, a new case series report demonstrates. The researchers say these misdiagnoses of fibromyalgia, occurring in a trio of Cushing’s syndrome patients across three countries, highlight the difficulties of diagnosing women who experience…

Fibromyalgia is remarkably more common in women than it is in men, but when it comes to feeling its effects, there is little difference between the sexes, according to results of a new study published in the journal Pain Research and Management. Fibromyalgia is a poorly understood disorder characterized by deep tissue pain, fatigue, depression…

Key Takeaways TNX-102 SL significantly improved pain, sleep, fatigue, and functioning in fibromyalgia patients, meeting primary and secondary endpoints in a phase 3 trial. The FDA approved TNX-102 SL in 2025, marking the first new fibromyalgia treatment in over 15 years and the fourth overall. Investigators evaluated whether targeting sleep-related neurophysiology with bedtime TNX-102 SL…

The US Food and Drug Administration (FDA) has approved cyclobenzaprine hydrochloride sublingual tablets (Tonmya; Tonix Pharmaceuticals) for the treatment of fibromyalgia in adults, marking the first new therapy for the condition in more than 15 years, according to a company news release. “The FDA approval of Tonmya as a first-line treatment for fibromyalgia represents a…

In 2001, Emily Shaules was an active, happy 25-year-old lawyer living in Chicago when a casual toss of her hair triggered a sudden, excruciating snap in her neck. Fearing she might have torn something or given herself whiplash, she headed to the emergency room, where she was diagnosed with a pulled muscle, prescribed Vicodin, and…

In the absence of a blood test, clinicians rely on patient-reported symptoms and a physical evaluation of pain to diagnose fibromyalgia. Researchers from Ohio State University have identified a “metabolic fingerprint” of the disease that increases the probability a reliable blood test may be designed. The investigators analyzed blood samples from 121 participants with similar…