Familial Mediterranean Fever Linked to Autoimmune and Rheumatologic Inflammatory Diseases
A recent study supports the use of long-term rheumatologic surveillance in patients with familial Mediterranean fever due to persistence of rheumatologic and autoimmune diseases despite treatment. By Deborah L. Ungerleider, MD, FAAP Familial Mediterranean fever (FMF) is caused by pathogenic variants in MEFV, which encodes pyrin. As pyrin regulates inflammasome activation, and interleukin-1ß (IL-1ß) and IL-18…