Now, scientists at Virginia Tech have found a way to switch it off in female mice by blocking a single pathway using compounds developed at the National Institutes of Health’s National Center for Advancing Translational Sciences. In a new study published in Pain, neuroscientist Ann Gregus and her team erased well-established pain behaviors by shutting down an enzyme…
Jacopo Maria Fontana 1. Department of Biomedical, Dental Sciences and Morphological and Functional Imaging, University of Messina, Messina, Italy. …
Antibiotic treatment, in particular Fluoroquinolones (FQs) have been reported as possible trigger for the development of painful sequelae, most of all due to tendon rupture, peripheral neuropathy and carpal tunnel syndrome (CTS). To date, there are no epidemiological studies about the development of musculoskeletal pain or Fibromyalgia Syndrome (FMS) following FQs treatment, while…
A recent study supports the use of long-term rheumatologic surveillance in patients with familial Mediterranean fever due to persistence of rheumatologic and autoimmune diseases despite treatment. By Deborah L. Ungerleider, MD, FAAP Familial Mediterranean fever (FMF) is caused by pathogenic variants in MEFV, which encodes pyrin. As pyrin regulates inflammasome activation, and interleukin-1ß (IL-1ß) and IL-18…
Fibromyalgia symptoms, including pain, can make restful sleep feel out of reach. In fact, 90 percent of people with fibromyalgia experience sleep disturbances, from difficulty dozing off to fragmented sleep. And poor sleep is associated with worsened symptoms. “Sleep is important to restore the body, but also to clear waste in the brain,” says Brian…
Is there anyone here who has been diagnosed with both osteoarthritis and fibromyalgia? Living with these two conditions at the same time can be challenging, especially because some of the symptoms can overlap. Osteoarthritis commonly affects the joints and may cause pain, stiffness, and difficulty with movement, while fibromyalgia can involve widespread pain, tenderness, fatigue,…
Axsome Therapeutics AXSM announced the initiation of the phase III study called FORWARD with the dosing of the first patient, evaluating AXS-14 (esreboxetine) for the management of fibromyalgia. AXS-14 is an oral, investigational drug, being developed to treat fibromyalgia and help reduce chronic pain and related symptoms by increasing norepinephrine levels in the brain.FORWARD is a…